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A centriolar lifeline

Nature Reviews Molecular Cell Biology volume 13, page 686 (2012)Cite this article

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The centrosome is the main microtubule-organizing centre in animal cells. Centrosomes are composed of two centrioles, which are microtubule-based structures, surrounded by pericentriolar material. Centrioles duplicate once every cell cycle. Electron microscopy studies performed by Robbins et al. over 40 years ago first described centriole duplication at the ultrastructural level in HeLa cells. A remarkable conserved feature reported at that time was that the newly formed procentriole is at a right angle to the mother centriole.

raises the intriguing possibility that the connective stalk sets the geometry of procentriole assembly

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ORIGINAL RESEARCH PAPERS

  1. Robbins, E., Jentzsch, G. & Micali, A. The centriole cycle in synchronized HeLa cells. J. Cell Biol. 36, 329–339 (1968)

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  2. Guichard, P., Chrétien, D., Marco, S. & Tassin, A. M. Procentriole assembly revealed by cryo-electron tomography. EMBO J. 29, 1565–1572 (2010)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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  1. UMR144, Centre national de la recherche scientifique (CNRS), Institut Curie, 12 rue Lhomond, Paris, 75005, France

    Renata Basto

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  1. Renata Basto
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Basto, R. A centriolar lifeline. Nat Rev Mol Cell Biol 13, 686 (2012). https://doi.org/10.1038/nrm3460

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