Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Journal Club
  • Published:

Stem cell renewal theory turns 60

Nature Reviews Molecular Cell Biology volume 14, page 754 (2013)Cite this article

Subjects

they were the first to emphasize that the maintenance of proliferating adult tissues could only be consistent with cell fate asymmetry

Following their seminal work in the early 1960s on bone marrow transplantation in irradiated mice, James Till and Ernest McCulloch have been rightly credited for defining the principles that underpin modern stem cell biology. However, for many, the foundations of the adult stem cell field were laid a decade earlier, in 1953, in a remarkable study by two other Canadians, Yves Clermont and Charles Philippe Leblond.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Clermont, Y. & Leblond, C. P. Renewal of spermatogonia in the rat. Am. J. Anat. 93, 475–501 (1953)

    Article  CAS  Google Scholar 

  2. Leblond, C. P. & Clermont, Y. Definition of the stages of the cycle of the seminiferous epithelium in the rat. Ann. NY Acad. Sci. 55, 548–573 (1952)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physics, Cavendish Laboratory, The Wellcome Trust/Cancer Research UK Gurdon Institute and Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, UK

    Benjamin D. Simons

Authors
  1. Benjamin D. Simons
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Benjamin D. Simons.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Related links

Related links

Related links in Nature Research

Siminovitch, L., McCulloch, E. A. & Till, J. E. The distribution of colony-forming cells among spleen colonies. J. Cell. Physiol. 62, 327–336 (1963)

Leblond, C. P. The time dimension in histology. Am. J. Anat. 116, 1–27 (1965)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Simons, B. Stem cell renewal theory turns 60. Nat Rev Mol Cell Biol 14, 754 (2013). https://doi.org/10.1038/nrm3706

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrm3706

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing