A new partner for BRCA1–BARD1

Schuldt, Alison

doi:10.1038/nrm3733

In Brief
Published: 20 December 2013

Centrosomes

A new partner for BRCA1–BARD1

Alison Schuldt

Nature Reviews Molecular Cell Biology volume 15, page 4 (2014)Cite this article

1056 Accesses
1 Altmetric
Metrics details

Subjects

Centrosome

Access through your institution

Buy or subscribe

In addition to being a key factor for DNA repair, the BRCA1 (breast cancer 1)–BARD1 (BRCA1-associated RING domain 1) heterodimer affects other cellular processes, including centrosome regulation. Using mass spectrometry, Matsuzawa et al. identify OLA1 (Obg-like ATPase 1) as a novel binding partner of BARD1 and then show that its loss results in amplification of centrosomes. It binds directly to BARD1, BRCA1 and γ-tubulin, and resides at both centrosomes and spindle poles. Notably, the authors show that a mutation of OLA1 found in the breast cancer cell line E168Q cannot restore control of centrosome number on OLA1 knockdown. Both this mutant and a familial BRCA1 cancer mutant show loss of the OLA1 interactions with BRCA1 and BARD1, suggesting that this is physiologically important.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

Purchase on SpringerLink
Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

Matsuzawa, A. et al. The BRCA1/BARD1-interacting protein OLA1 functions in centrosome regulation. Mol. Cell 53, 1–14 10.1016/j.molcel.2013.10.028(2013)
Article CAS Google Scholar

Download references

Authors