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Pitfalls in isolating lipid rafts

Nature Reviews Neuroscience volume 8, page 567 (2007)Cite this article

A Correspondence to this article was published on 01 July 2007

Sirs

Our second comment is on our previous work, which, as the authors correctly cited, showed that psychopharmacological drugs such as antidepressants and antipsychotics can accumulate in raft-like domains9. We would like to point out that not all psychopharmacological drugs accumulate in these microdomains. This differential enrichment of antidepressants and antipsychotics in lipid rafts may contribute to their effects on neurotransmitter receptor signalling — for example, the allosteric modulation of ligand-gated ion channels — and thus to the effects of psychopharmacological compounds on neuroplasticity.

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Figure 1: Separation of caveolin 1 and flotillin 1 from the transferrin receptor in fractions obtained from density gradient centrifugation.
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Authors and Affiliations

  1. Department of Psychiatry, Ludwig-Maximilian-University, Munich, 80336, Germany

    Caroline Nothdurfter & Rainer Rupprecht

  2. Max-Planck-Institute of Psychiatry, Munich, 80804, Germany

    Caroline Nothdurfter, Gerhard Rammes, Theo Rein & Rainer Rupprecht

  3. Department of Anesthesiology, Technical University of Munich, Munich, 81675, Germany

    Gerhard Rammes

Authors
  1. Caroline Nothdurfter
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  2. Gerhard Rammes
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  4. Rainer Rupprecht
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Correspondence to Rainer Rupprecht.

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Nothdurfter, C., Rammes, G., Rein, T. et al. Pitfalls in isolating lipid rafts. Nat Rev Neurosci 8, 567 (2007). https://doi.org/10.1038/nrn2059-c1

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