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Mineral metabolism

Proteinuria increases phosphate retention

Nature Reviews Nephrology volume 11, page 2 (2015)Cite this article

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A pathophysiologic link exists between proteinuria and renal phosphate handling, say researchers. An analysis of 1,738 patients with chronic kidney disease identified albuminuria ≥300 mg per 24 h as an independent predictor of high phosphate levels. Using both rat and mouse animal models, the researchers showed that proteinuria-induced phosphate retention was partly caused by enhanced sodium-dependent phosphate transport protein 2A expression and decreased fibroblast growth factor (FGF)-23 activity. They suggest that high levels of phosphate and FGF-23 in patients with proteinuria might contribute to their increased risk of cardiovascular disease.

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References

  1. de Seigneux, S. et al. Proteinuria increases plasma phosphate by altering its tubular handling. J. Am. Soc. Nephrol. 10.1681/ASN.2014010104

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Proteinuria increases phosphate retention. Nat Rev Nephrol 11, 2 (2015). https://doi.org/10.1038/nrneph.2014.214

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