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Motor neuron disease

Activated protein C slows ALS-like disease in an animal model

Nature Reviews Neurology volume 5, page 636 (2009)Cite this article

Zhong, Z. et al. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J. Clin. Invest. 119, 3437–3449 (2009).

Administration of activated protein C (APC) in a mouse model of amyotrophic lateral sclerosis (ALS) after the animals show signs of disease onset not only slows progression of their symptoms, but also extends their overall survival. “I think these findings may change the way forward with developing new treatments for ALS in the future. Once we identify the most effective form of APC, we expect to get to clinical trials within 4–5 years,” reports senior author Berislav Zlokovic (University of Rochester Medical Center, New York, USA).

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Figure 1: Capillary leakage of serum proteins in a mouse model of amyotrophic lateral sclerosis.
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  1. Kathryn Senior
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Senior, K. Activated protein C slows ALS-like disease in an animal model. Nat Rev Neurol 5, 636 (2009). https://doi.org/10.1038/nrneurol.2009.184

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