News & Comment

Loss of TDP43 from the nucleus in amyotrophic lateral sclerosis and frontemporal dementia leads to changes in polyadenylation that alter mRNA processing, according to new research.

Recent research indicates that the brain-first and body-first subtypes of Parkinson disease can be distinguished by patterns of cutaneous α-synuclein deposition.

A new study indicates that physical activity reduces cognitive decline, possibly through attenuation of tau accumulation in the brain.

A drug that targets lysosomal damage could boost the effects of gene therapy for Duchenne muscular dystrophy, according to new research.

Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a broad spectrum of diversity, equity and inclusion initiatives. We spoke with Victor Rivera from Baylor College of Medicine about his work to address disparities in multiple sclerosis care in Latin American and other populations.

Developmental trajectories and genetic architectures differ between inidividuals with autism who are diagnosed early or later in life, new research has shown.

Lipids derived from extracellular vesicles in adipose tissue from people with obesity can promote amyloid-β aggregation, according to new research.

PET imaging of synaptic vesicle protein 2A could enable visualization of grey matter pathology in multiple sclerosis, new work has shown.

The C9orf72 hexanucleotide expansion that causes amyotrophic lateral sclerosis (ALS) compromises microglial function, new research has shown.

Serial analysis of glioblastoma tissue during treatment can help to reveal and monitor treatment responses, according to a new study.

We are celebrating 20 years of Nature Reviews Neurology with our November 2025 issue. On reaching this milestone, we have refined and renewed our mission, and we continue to evolve the journal to support the translation of research into real-world benefits.

To mark the 20th anniversary of Nature Reviews Neurology, we have asked leaders of neurological societies across the world to reflect on progress over the past two decades and consider what the future holds for neurology in their region. Here, we speak to Fernando Cendes, Vice President of the Pan American Federation of Neurology.

To mark the 20th anniversary of Nature Reviews Neurology, we have asked leaders of neurological societies across the world to reflect on progress over the past two decades and consider what the future holds for neurology in their region. Here, we speak to Elena Moro, President of the European Academy of Neurology.

To mark the 20th anniversary of Nature Reviews Neurology, we have asked leaders of neurological societies across the world to reflect on progress over the past two decades and consider what the future holds for neurology in their region. Here, we speak to Christopher Chen, President of the Asian and Oceanian Association of Neurology.

To mark the 20th anniversary of Nature Reviews Neurology, we have asked leaders of neurological societies across the world to reflect on progress over the past two decades and consider what the future holds for neurology in their region. Here, we speak to Natalia S. Rost, President of the American Academy of Neurology.

To mark the 20th anniversary of Nature Reviews Neurology, we have asked leaders of neurological societies across the world to reflect on progress over the past two decades and consider what the future holds for neurology in their region. Here, we speak to Amina Gargouri and Riadh Gouider, President and Honorary President of the Pan-Arab Union of Neurological Societies.

To mark the 20th anniversary of Nature Reviews Neurology, we have asked leaders of neurological societies across the world to reflect on progress over the past two decades and consider what the future holds for neurology in their region. Here, we speak to Lawrence Tucker and Augustina Charway-Felli, President and Past President, respectively, of the African Academy of Neurology.

Cerebellar pathology in people with type 1 spinal muscular atrophy (SMA) might contribute to motor and social communication impairments associated with the disease, according to a recent study published in Brain.

Autologous haematopoietic stem cell transplantation (AHSCT) offers effective therapy for people with multiple sclerosis (MS), according to new real-world data.

Glioblastomas can shift glucose metabolism from tricarboxylic acid cycle (TCA) oxidation and neurotransmitter synthesis to growth-promoting pathways, according to new research published in Nature.