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Epilepsy

Nonsynaptic mechanisms for interictal discharges in drug-intractable epilepsy

Nature Reviews Neurology volume 6, page 61 (2010)Cite this article

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A Correction to this article was published on 01 April 2010

Roopun et al. have identified a nonsynaptic mechanism that is responsible for interictal discharges in drug-intractable epilepsy. Their findings might explain why drugs are ineffective in such cases, and could aid the development of new treatments.

...VFOs occurred at the onset of interictal events ... this leads to “a state of pathological hyperexcitability”

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ORIGINAL RESEARCH PAPERS

  1. Roopun, A. K. et al. A nonsynaptic mechanism underlying interictal discharges in human epileptic neocortex. Proc. Natl Acad. Sci. USA doi:10.1073/pnas.0912652107

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  1. Eleanor Beal
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Beal, E. Nonsynaptic mechanisms for interictal discharges in drug-intractable epilepsy. Nat Rev Neurol 6, 61 (2010). https://doi.org/10.1038/nrneurol.2009.223

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