Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Epilepsy

Antiepileptic drugs have a dose-dependent association with malformations in offspring of women with epilepsy

Nature Reviews Neurology volume 7, page 420 (2011)Cite this article

Subjects

The risk of malformations in offspring is increased in a dose-dependent manner by monotherapy with any of the four major antiepileptic drugs during pregnancy. This association was identified by the EURAP Study Group, in a large observational study using data from physicians in many countries.

...better understanding ... will help to make treatment both as safe and as effective as possible

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPER

  1. Tomson, T. et al. Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol. 10, 609–617 (2011)

    Article  CAS  Google Scholar 

Download references

Authors
  1. Eleanor Beal
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Beal, E. Antiepileptic drugs have a dose-dependent association with malformations in offspring of women with epilepsy. Nat Rev Neurol 7, 420 (2011). https://doi.org/10.1038/nrneurol.2011.103

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrneurol.2011.103

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing