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Multiple sclerosis

Study reinforces need for contraception in women taking fingolimod

Nature Reviews Neurology volume 10, page 125 (2014)Cite this article

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...we strongly recommend that pregnancy be avoided during treatment with fingolimod...

Fingolimod—one of a series of new oral medications for the treatment of multiple sclerosis (MS)—may be linked to an increased risk of teratogenicity when exposure occurs during the early stages of pregnancy, a new study indicates. “Given the five cases of abnormal fetal development seen among 66 pregnancies, we strongly recommend that pregnancy be avoided during treatment with fingolimod,” states senior investigator William Collins. He points out, however, that firm conclusions about the safety of fingolimod during pregnancy are not possible owing to the small number of patients becoming pregnant during trials of this drug.

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References

  1. Karlsson, G. et al. Pregnancy outcomes in the clinical development program of fingolimod in multiple sclerosis. Neurology 10.1212/WNL.0000000000000137

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  1. Bryony Jones
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Jones, B. Study reinforces need for contraception in women taking fingolimod. Nat Rev Neurol 10, 125 (2014). https://doi.org/10.1038/nrneurol.2014.22

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