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Stroke

Kv1.3 inhibition shows therapeutic potential in animal models of ischaemic stroke

Nature Reviews Neurology volume 14, page 127 (2018)Cite this article

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Inhibition of the voltage-gated K+ channel Kv1.3 can reduce secondary brain injury after ischaemic stroke, according to a new study published in Annals of Clinical and Translational Neurology. Kv1.3 is upregulated on activated 'M1-like' microglia, which are thought to contribute to inflammatory damage following brain ischaemia and reperfusion. Researchers at the University of California, Davis, USA, tested the small-molecule Kv1.3 inhibitor PAP-1 in mouse and rat models of ischaemic stroke. They found that the drug reduced the size of the infarct and ameliorated neurological deficits in both models. The authors conclude that Kv1.3 inhibition is a promising approach, but it needs to undergo additional testing in models that more closely resemble human stroke before it can enter clinical trials.

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References

  1. Chen, Y.-J. et al. Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. Ann. Clin. Transl Neurol. https://doi.org/10.1002/acn3.513 (2017)

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  1. Heather Wood
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Wood, H. Kv1.3 inhibition shows therapeutic potential in animal models of ischaemic stroke. Nat Rev Neurol 14, 127 (2018). https://doi.org/10.1038/nrneurol.2018.7

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