Table 2 Association of the T Allele of rs900400 with Belfast offspring sum of and individual skinfold thicknesses at birth, 2 years and 6 years

From: The chromosome 3q25 locus associated with fetal adiposity is not associated with childhood adiposity

 

2-years old cohort (n=293)

6-years old cohort (n=350)

  

Newborn

2 years

 

Newborn

6 years

Skinfold

AF

P-value

Beta (s.e.)

P-value

Beta (s.e.)

AF

P-value

Beta (s.e.)

P-value

Beta (s.e.)

Sum

0.64

4.8 × 10−4

0.0248 (0.0071)

0.06

−0.0149 (0.0077)

0.63

2.8 × 10−4

0.0235 (0.0064)

0.86

0.0019 (0.0108)

Triceps

0.64

3.4 × 10−3

0.0215 (0.0073)

0.03

−0.0160 (0.0074)

0.63

1.8 × 10−3

0.0206 (0.0065)

0.97

−0.0004 (0.0091)

Subscapular

0.64

2.0 × 10−4

0.0288 (0.0077)

0.52

−0.0064 (0.0099)

0.63

5.0 × 10−4

0.0246 (0.0070)

0.98

0.0003 (0.0128)

Flank/Suprailiac

0.64

5.0 × 10−3

0.0232 (0.0083)

0.14

−0.0170 (0.0114)

0.63

1.0 × 10−3

0.0246 (0.0076)

0.70

0.0056 (0.0105)

  1. Abbreviation: AF, allele frequency (T allele of rs900400). Beta-regression coefficient with logarithmically transformed sum of skinfolds as dependent variable and SNP included in an additive genetic model. Covariates included in the model were age, ancestry, gender, gestational age at delivery, parity, maternal smoking status and alcohol intake during pregnancy, maternal age, body mass index, height and mean arterial blood pressure at the time of oral glucose tolerance test. exp(β) represents the multiplicative effect on sum of skinfolds associated with each copy of the allele after adjustment for all covariates.
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