Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Brachytherapy for advanced prostate cancer bleeding

Abstract

Advanced prostate cancer patients frequently deal with intractable prostatic bleeding which is a difficult problem to manage. Intraurethral high-dose rate (HDR) brachytherapy may palliate this condition. Advanced prostate cancer patients with intractable prostatic bleeding were offered brachytherapy with Iridium-192 using a Micro-selectron HDR machine. During a 5-year period, analysis was performed in 23 patients with a median age and Gleason score of 78 years and 9, respectively. Following brachytherapy, haematuria resolved in 19 of the 23 patients and was recurrence free at 6 months. Intraurethral HDR brachytherapy is a potentially effective modality for treating haematuria in patients with advanced prostate cancer.

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3
Figure 4

Similar content being viewed by others

References

  1. American Cancer Society. Cancer Facts and Figures. American Cancer Society: Atlanta, GA. Available at: http://www.cancer.org/docroot/STT/stt_O.asp.

  2. Salonia A, Gallina A, Camerota T, Picchio M, Freschi M, DaPozzo L et al. Bone metastases are infrequent in patients with newly diagnosed prostate cancer: analysis of their clinical and pathologic features. Urology 2006; 68: 362–366.

    Article  PubMed  Google Scholar 

  3. Sur RK, Donde B, Levin VC, Mannell A . Fractionated high dose rate intraluminal brachytherapy in palliation of advanced esophageal cancer. Int J Radiat Oncol Biol Phys 1998; 40: 447–453.

    Article  CAS  PubMed  Google Scholar 

  4. Kohek PH, Pakisch B, Glanzer H . Intraluminal irradiation in the treatment of malignant airway obstruction. Eur J Surg Oncol 1994; 20: 674–680.

    CAS  PubMed  Google Scholar 

  5. Gerbaulet A, Haie-Meder C, Bruggmoser G, Laaff H, Kluger UW, Roth R et al. Brachytherapy in cancer of the urethra. Ann Urol (Paris) 1994; 28: 312–317.

    CAS  Google Scholar 

  6. Sharma V, Mahantshetty U, Dinshaw KA, Despande R, Sharma S . Palliation of advanced/recurrent esophageal carcinoma with high dose-rate brachytherapy. Int J Radiat Oncol Biol Phys 2002; 52: 310–315.

    Article  PubMed  Google Scholar 

  7. Sur RK, Levin CV, Donde B, Sharma V, Miszczyk L, Nag S . Prospective randomized trial of HDR brachytherapy as a sole modality in palliation of advanced esophageal carcinoma—an international atomic energy agency study. Int J Radiat Oncol Biol Phys 2002; 53: 127–133.

    Article  PubMed  Google Scholar 

  8. Chen Y . HDR-192Ir intraluminal brachytherapy in treatment of malignant obstructive jaundice. World J Gastroenterol 2004; 10: 3506–3510.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Macha HN, Wahlers B, Reichle C, von Zwehl D . Endobronchial radiation therapy for obstructing malignancies: ten years' experience with iridium-192 high-dose radiation brachytherapy afterloading technique in 365 patients. Lung 1995; 173: 271–280.

    Article  CAS  PubMed  Google Scholar 

  10. Mehta M, Petereit D, Chosy L, Harmon M, Fowler J, Shahabi S et al. Sequential comparison of low dose rate and hyperfractionated high dose rate endobronchial radiation for malignant airway occlusion. Int J Radiat Oncol Biol Phys 1992; 23: 133–139.

    Article  CAS  PubMed  Google Scholar 

  11. Lo TC, Girshovich L, Healey GA, Beamis Jr JF, Webb-Johnson DC, Villaneuva AG et al. Low dose rate versus high dose rate intraluminal brachytherapy for malignant endobronchial tumors. Radiother Oncol 1995; 35: 193–197.

    Article  CAS  PubMed  Google Scholar 

  12. Chang LF, Horvath J, Peyton W, Ling SS . High dose rate afterloading intraluminal brachytherapy in malignant airway obstruction of lung cancer. Int J Radiat Oncol Biol Phys 1994; 28: 589–596.

    Article  CAS  PubMed  Google Scholar 

  13. Foley SJ, Soloman LZ, Wedderburn AW, Kashif KM, Summerton D, Basketter V et al. A prospective study of the natural history of hematuria associated with benign prostatic hyperplasia and the effect of finasteride. J Urol 2000; 163: 496–498.

    Article  CAS  PubMed  Google Scholar 

  14. Andriole GL, Humphrey P, Ray P, Gleave ME, Trachtenberg J, Thomas LN et al. Effect of the dual 5alpha-reductase inhibitor dutasteride on markers of tumor regression in prostate cancer. J Urol 2004; 172: 915–919.

    Article  CAS  PubMed  Google Scholar 

  15. Kaya C, Ozyurek M, Turkeri LN . Comparison of microvessel densities in rat prostate tissues treated with finasteride, bicalutamide and surgical castration: a preliminary study. Int J Urol 2005; 12: 194–198.

    Article  CAS  PubMed  Google Scholar 

  16. Rannikko A, Petas A, Taari K . Tranexamic acid in control of primary hemorrhage during transurethral prostatectomy. Urology 2004; 64: 955–958.

    Article  PubMed  Google Scholar 

  17. Gibbons RP, Mason JT, Correa RJ, Cummings KB, Taylor WJ, Hafermann MD et al. Carcinoma of the prostate: local control with external beam radiation therapy. J Urol 1979; 121: 310–312.

    Article  CAS  PubMed  Google Scholar 

  18. Jenkins CN, McIvor J . Survival after embolisation if the internal iliac arteries in ten patients with severe haematuria due to pelvic carcinoma. Clin Radiol 1996; 51: 865–868.

    Article  CAS  PubMed  Google Scholar 

  19. Crain DS, Amling CL, Kane CJ . Palliative transurethral prostate resection for bladder outlet obstruction in patients with locally advanced prostate cancer. J Urol 2004; 171: 668–671.

    Article  PubMed  Google Scholar 

  20. Gilling PJ, Cass CB, Cresswell MD, Fraundorfer MR . Holmium laser resection of the prostate: preliminary results of a new method for the treatment of benign prostatic hyperplasia. Urology 1996; 47: 48–51.

    Article  CAS  PubMed  Google Scholar 

  21. Hai M, Malek RS . Photoselective vaporization of the prostate: Initial experience with a new 80watt KTP laser for the treatment of benign prostatic hyperplasia. J Endourol 2003; 17: 93–96.

    Article  PubMed  Google Scholar 

  22. Gilling PJ, Fraundorfer MR . Holmium laser prostatectomy: a technique in evolution. Curr Opin Urol 1998; 8: 11–15.

    Article  CAS  PubMed  Google Scholar 

  23. Elzayat E, Habib E, Elhilali M . Holmium laser enucleation of the prostate in patients on Anticoagulant therapy or with bleeding disorders. J Urol 2006; 175: 1428–1432.

    Article  CAS  PubMed  Google Scholar 

  24. Volkan T, Ihsan TA, Yilmaz O, Emin O, Selcuk S, Koray K et al. Short term outcomes of high power (80 W) potassium-titanyl-phosphate laser vaporization of the prostate. Eur Urol 2005; 48: 608–613.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R Thurairaja.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thurairaja, R., Pocock, R., Crundwell, M. et al. Brachytherapy for advanced prostate cancer bleeding. Prostate Cancer Prostatic Dis 11, 367–370 (2008). https://doi.org/10.1038/pcan.2008.12

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/pcan.2008.12

Keywords

Search

Quick links