Abstract
In this study, electrospun composite nanofibers containing nanoparticles for the programmable release of dual drugs were successfully fabricated through a one-step, single-nozzle electrospinning technique. Field-emission scanning electron microscopy and scanning electron microscopy were used to examine the morphology of the nanoparticles and electrospun nanofibers, respectively. The distribution of nanoparticles in the composite nanofibers was evaluated by fluorescence microscopy and laser scanning confocal microscopy. The results indicate that the nanoparticles were encapsulated within the composite nanofibers, forming a core–sheath structure. The different release behaviors of the drugs were ascribed to their varying distribution in the nanofibers and their interaction with carriers. A programmable release of both drugs was also achieved by adjusting the preparation process of the electrospinning solution. Composite nanofibers that can provide a platform for dual-drug loading and the programmed release of each drug may find application in drug delivery systems or in the tissue-engineering field.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Wei, M., Kang, B., Sung, C. M. & Mead, J. Core-sheath structure in electrospun nanofibers from polymer blends. Macromol. Mater. Eng. 291, 1307–1314 (2006).
Taepaiboon, P., Rungsardthong, U. & Supaphol, P. Vitamin-loaded electrospun cellulose acetate nanofiber mats as transdermal and dermal therapeutic agents of vitamin A acid and vitamin E. Eur. J. Pharm. Biopharm. 67, 387–397 (2007).
Angeles, M., Cheng, H. S. & Velankar, S. S. Emusion electrospinning: composite fibers from drop breakup during electrospinning. Polym. Adv. Technol. 9, 728–733 (2008).
Yoo, H. S., Kim, T. G. & Park, T. G. Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery. Adv. Drug Deliv. Rev. 61, 1033–1042 (2009).
Chew, S. Y., Wen, Y., Dzenis, Y. & Leong, K. W. The role of electrospinning in the emerging field of nanomedicine. Curr. Pharm. Des. 12, 4751–4770 (2006).
Sill, T. J. & von Recum, H. A. Electrospinning: applications in drug delivery and tissue engineering. Biomaterials 29, 1989–2006 (2008).
Srikar, R., Yarin, A. L., Megaridis, C. M., Bazilevsky, A. V. & Kelley, E. Desorption-limited mechanism of release from polymer nanofibers. Langmuir 24, 965–974 (2008).
Jo, E., Lee, S., Kim, K. T., Won, Y. S., Kim, H. S., Cho, E. C. & Jeong, U. Core-sheath nanofibers containing colloidal arrays in the core for programmable multi-agent delivery. Adv. Mater. 21, 968–972 (2009).
Jaklenec, A., Hinckfuss, A., Bilgen, B., Ciombor, D. M., Aaron, R. & Mathiowitz, E. Sequential release of bioactive IGF-I and TGF-b1 from PLGA microsphere-based scaffolds. Biomaterials 29, 1518–1525 (2008).
Ahmed, F., Pakunlu, R. I., Brannan, A., Bates, F., Minko, T. & Discher, D. E. Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug. J. Control. Release 116, 150–158 (2006).
Thakura, R. A., Florekb, C. A., Kohnb, J. & Michniak, B. B. Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing. Int. J. Pharm. 364, 87–93 (2008).
Su, Y., Li, Q., Liu, S. P., Mo, X. & Seeram, R. Controlled release of dual drugs from emulsion electrospun nanofibrous mats. Colloid Surf. B 73, 376–381 (2009).
Dong, B., Smith, M. E. & Wnek, G. E. Encapsulation of multiple biological compounds within a single electrospun fiber. Small 5, 1508–1512 (2009).
Qi, L. F., Xu, Z. R., Jiang, X., Hu, C. H. & Zou, X. F. Preparation and antibacterial activity of chitosan nanoparticles. Carbohyd. Res. 339, 2693–2700 (2004).
Papadimitriou, S., Bikiaris, D., Avgoustakis, K., Karavas, E. & Georgarakis, M. Chitosan nanoparticles loaded with dorzolamide and pramipexole. Carbohyd. Polym. 73, 44–54 (2008).
Zhao, J. Y. & Wu, J. M. Preparation and characterization of the fluorescent chitosan nanoparticle probe. Chin. J. Anal. Chem. 34, 1555–1559 (2006).
Zhang, Q. H., Zhen, J., Chang, Z. J., Zhu, M. F., Mo, X. M. & Chen, D. J. Electrospun carbon nanotube composite nanofibres with uniaxially aligned arrays. Nanotechnology 18, 115611 (2007).
Shah, S., Pal, A., Kaushik, V. K. & Devi, S. Preparation and characterization of venlafaxine hydrochloride-loaded chitosan nanoparticles and in vitro release of drug. J. Appl. Polym. Sci. 112, 2876–2887 (2009).
Li H. & Gao, C. Y. Preparation and properties of ionically cross-linked chitosan nanoparticles. Polym. Adv. Technol. 20, 613–619 (2009).
Qi, H. X., Hu, P., Xu J. & Wang, A. J. Encapsulation of drug reservoirs in fibers by emulsion electrospinning: morphology characterization and preliminary release assessment. Biomacromolecules 7, 2327–2330 (2006).
Saeed, K., Park, S. Y., Lee, H. J., Baek, J. B. & Huh, W. S. Preparation of electrospun nanofibers of carbon nanotube/polycaprolactone nanocomposite. Polymer 47, 8019–8025 (2006).
Shao, C. L., Kim, H. Y., Gong, J., Ding, B., Lee, D. R. & Park, S. J. Fiber mats of poly(vinyl alcohol)/silica composite via electrospinning. Mater. Lett. 57, 1579–1584 (2003).
Teo, W. E. & Ramakrishna, S. Electrospun nanofibers as a platform for multifunctional, hierarchically organized nanocomposite. Comp. Sci. Technol. 69, 1804–1817 (2009).
Xu, X. L., Chen, X. S., Liu, A. X., Hong, Z. K. & Jing, X. B. Electrospun poly(L-lactide)-grafted hydroxyapatite/poly(L-lactide) nanocomposite fibers. Eur. Polym. J. 43, 3187–3196 (2007).
Xu, X. L., Chen, X. S., Ma, P. A., Wang, X. R. & Jing, X. B. The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning. Eur. J. Pharm. Biopharm. 70, 165–170 (2008).
Lim, J. M., Moon, J. H., Yi, G. R., Heo, C. J. & Yang, S. M. Fabrication of one-dimensional colloidal assemblies from electrospun nanofibers. Langmuir 22, 3345–3349 (2006).
Tungprapa, S., Jangchud, I. & Supaphol, P. Release characteristics of four model drugs from drug-loaded electrospun cellulose acetate fiber mats. Polymer 48, 5030–5041 (2007).
Gandhi, M., Srikar, R., Yarin, A. L., Megaridis, C. M. & Gemeinhart, R. A. Mechanistic examination of protein release from polymer nanofibers. Mol. Pharm. 6, 641–647 (2009).
Hughes, G. A. Nanostructure-mediated drug delivery. Nanomedicine 1, 22–30 (2005).
Taepaiboon, P., Rungsardthong, U. & Supaphol, P. Drug-loaded electrospun mats of poly(vinyl alcohol) fibers and their release characteristics of four model drugs. Nanotechnology 17, 2317–2329 (2006).
Zeng, J., Yang, L. X., Liang, Q. Z., Zhang, X. F., Guan, H. L., Xu, X. L., Chen, X. S. & Jing, X. B. Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation. J. Control Release 105, 43–51 (2005).
Acknowledgements
This study was supported by the Fundamental Research Funds for the Central Universities (Project No. CDJRC10230003) and National Natural Science Foundation of China (Project No. 30901977). The authors are grateful to Professor Li Yang and doctoral student Linhao Li for their experimental equipment and useful suggestions. The authors are also very thankful to Dr Gurinder K Singh for critically evaluating the manuscript.
Author information
Authors and Affiliations
Corresponding author
Additional information
Supplementary Information accompanies the paper on Polymer Journal website
Supplementary information
Appendix
Appendix
Ultraviolet calibration curves of rhodamine B and naproxen in phosphate buffer saline (pH=7.4).
Rights and permissions
About this article
Cite this article
Wang, Y., Qiao, W., Wang, B. et al. Electrospun composite nanofibers containing nanoparticles for the programmable release of dual drugs. Polym J 43, 478–483 (2011). https://doi.org/10.1038/pj.2011.11
Received:
Revised:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/pj.2011.11
Keywords
This article is cited by
-
Selenium nanoparticles incorporated in nanofibers media eliminate H1N1 activity: a novel approach for virucidal antiviral and antibacterial respiratory mask
Environmental Science and Pollution Research (2023)
-
Electrospun Nanofibers for Dual and Local Delivery of Neuroprotective Drugs
Fibers and Polymers (2021)
-
Colored Polymeric Nanofiber Loaded with Minoxidil Sulphate as Beauty Coverage and Restoring Hair Loss
Scientific Reports (2020)
-
Polyacrylonitrile (PAN) nanofibres spun with copper nanoparticles: an anti-Escherichia coli membrane for water treatment
Applied Microbiology and Biotechnology (2018)
-
Magnetic nanoparticle-loaded electrospun poly(ε-caprolactone) nanofibers for drug delivery applications
Applied Nanoscience (2018)
