Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Abstract 1835Poster Session I, Saturday, 5/1 (poster 45)
The benefit of partial liquid ventilation PLVSM has been shown in a variety of respiratory diseases in animal and human studies. Although the amount of PFC in the lungs should be kept stable during PLV, PFC is lost due to evaporative loss (EL) which depends on ventilation strategy, positioning, and PFC vapor pressure (PV). Since PV rises exponentially with temperature, we hypothesized that PFC EL profile over time is dependent upon temperature. To quantify the effect of temperature on EL, 17 ml/kg of perflubron (LiquiVent®) was instilled endotracheally into anesthetized, juvenile rabbits (N = 8; wt= 1.76 ± 0.18 SE kg) over 5-10 minutes after the animals were stabilized at 27°C (core temperature, TC) for the hypothermic group and 37°CTC for the normothermic group. The ventilation strategy was to keep the minute ventilation at 300 ml/kg/min and position (supine) constant. Gas exchange and acid base balance were maintained in a physiologic range. TC was measured with a thermodilution catheter placed I.V. The content of PFC in the expired gas was measured with a previously described thermal detector device and the EL was calculated. Radiographic images were taken at 4 hrs of PLV. EL (ml/kg/hr) of PFC (mean ± SE): (Table)
Mandl, M., Harris, K., Wolfson, M. et al. Perfluorochemical (PFC) Evaporation from the Lungs: Effect of Body Temperature.
Pediatr Res45, 311 (1999). https://doi.org/10.1203/00006450-199904020-01852
