Cerebral Perinatal White Matter Injury of the Preterm Infant Alters Subsequent Microstructural Brain Development

Huppi, Petra S; Inder, Terrie E; Maier, Stephan E; Zientara, Gary P; Murphy, Brendan; Jolesz, Ferenc A; Volpe, Joseph J

doi:10.1203/00006450-199904020-02038

The American Pediatric Society and the Society for Pediatric Research 1999 Abstract
Published: 01 April 1999

Cerebral Perinatal White Matter Injury of the Preterm Infant Alters Subsequent Microstructural Brain Development

Petra S Huppi^1,2,
Terrie E Inder^1,2,
Stephan E Maier^1,2,
Gary P Zientara^1,2,
Brendan Murphy^1,2,
Ferenc A Jolesz^1,2 &
…
Joseph J Volpe^1,2

Pediatric Research volume 45, page 343 (1999)Cite this article

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Abstract 2022 Perinatal Brain Injury: Patterns and Mechanisms Platform, Tuesday, 5/4

Objective: The full impact of cerebral white matter injury (WMI) in the premature infant on the subsequent development of cerebral cortex and white matter is unknown. The possibilities that cerebral WMI might impair subsequent progression of cerebral axonal fiber development and myelination are suggested by pathological data⁽¹⁾. We used diffusion tensor MRI⁽²⁾ and quantitative volumetric 3D-MRI⁽³⁾ to assess these possible effects of cerebral WMI on cerebral white matter development.

Ref:

Marin-Padilla M, . Developmental neuropathology and impact of perinatal brain damage. 2. White matter lesions of the neocortex. J Neuropathol Exp Neurol, 56( 3): 219–235, 1997
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Huppi PS, Maier SE, Peled S, Zientara GP, Jolesz FA, et al. Microstructural development of human newborn cerebral white matter assessed in vivo by diffusion tensor magnetic resonance imaging. Pediatr Res, 44( 584–590, 1998
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Huppi PS, Warfield S, Barnes PD, Zientara GP, Jolesz FA, et al. Quantitative magnetic resonance imaging of brain development in premature and mature newborns. Ann Neurol, 43( 224–235, 1998
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Authors and Affiliations

Newborn Medicine/Neurology, Neurology, Harvard Medical School, Boston, MA
Petra S Huppi, Terrie E Inder, Stephan E Maier, Gary P Zientara, Brendan Murphy, Ferenc A Jolesz & Joseph J Volpe
Radiology, Brigham and Women's Hospital, Boston, MA
Petra S Huppi, Terrie E Inder, Stephan E Maier, Gary P Zientara, Brendan Murphy, Ferenc A Jolesz & Joseph J Volpe

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Petra S Huppi
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Terrie E Inder
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Stephan E Maier
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Gary P Zientara
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Brendan Murphy
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Ferenc A Jolesz
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Joseph J Volpe
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Huppi, P., Inder, T., Maier, S. et al. Cerebral Perinatal White Matter Injury of the Preterm Infant Alters Subsequent Microstructural Brain Development. Pediatr Res 45, 343 (1999). https://doi.org/10.1203/00006450-199904020-02038

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Issue date: 01 April 1999
DOI: https://doi.org/10.1203/00006450-199904020-02038

Cerebral Perinatal White Matter Injury of the Preterm Infant Alters Subsequent Microstructural Brain Development

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