Abstract
Background: Insulin resistance is known to affect endothelial function in adults leading to cardiovascular disease. It is important to assess adolescent changes during puberty and how they relate to carbohydrate and insulin physiology.
Design/Methods: Strain gauge plethysmography and radial arterial tonometry were used to determine the percent change in forearm vascular resistance (mean arterial pressure/forearm blood flow; reactive hyperemia; RH) following 5 min of upper arm vascular occlusion after overnight fast in 14 healthy Caucasians (age 14.3±2.0 years; BMI 19.8±3.0 kg/m2; mean SD) the frequently sampled intravenous glucose tolerance test, IVGTT, and minimum model were used to assess insulin sensitivity (SI), glucose effectiveness (SG) and acute insulin response to glucose (AIRG).
Results: The RH was negatively correlated with AIRG (r=-0.74, p=0.022) and tended to positively correlate with log disposition index (AIRGxSI) (r=0.62, p=0.056) (figure 1). No relations between RH and SG or SI.
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Conclusions: These results demonstrate that Caucasian adolescents with a high acute insulin response have poorer endothelial function. Thus high insulin levels may impair endothelial function and increase risk of cardiovascular disease. The relationship between DI and RH suggest that even in adolescence there is a close relationship between risk for type 2 diabetes and cardiovascular disease.
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Duck, M., Hoffman, R. 10 Insulin Response to Glucose Predicts Endothelial Dysfunction in Adolescence. Pediatr Res 58, 817 (2005). https://doi.org/10.1203/00006450-200510000-00040
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DOI: https://doi.org/10.1203/00006450-200510000-00040
