Abstract
Aim: To assess the effects of tracheal occlusion (TO) on lung mechanics in a sham controlled newborn rabbit model of CDH.
Methods: On day 23/31, CDH was induced by ex-utero surgery. Controls received a sham thoracotomy (SHAMCDH). On day 28 fetuses were randomly assigned to TO or SHAM-TO. Non-operated littermates served as controls (NOP). Fetuses were delivered on day 31 for mechanical ventilation and measurement of lung mechanics (dynamic and static compliance (C, Cst), resistance (R), total lung capacity (TLC), and impedance (forced oscillation technique)), and lung to body weight ratio (LBWR). Airway resistance (R(aw)), elastance (H(L)), tissue damping (G(L)) and hysteresivity (G(L)/ H(L)) were calculated from impedance data.
Results: There was no difference in birth weight but LBWR was significantly increased by TO in CDH and SHAM-CDH animals as compared to fetuses without TO or NOP. The parameters of lung mechanics after 30min of ventilation are shown below (mean, *p< 0.05 as compared to NOP).
Summary: In this rabbit model of lung hypoplasia, TO had a substantial effect on lung volume and TLC. However, TO seemed to have a negative effect on tissue damping and elastance indicating increased tissue forces.
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Herber-Jonat, S., Vuckovic, A., Rühl, I. et al. 517 Characterisation of Lung Mechanics After Fetal Tracheal Occlusion in Newborn Rabbits with Lung Hypoplasia Induced by Diaphragmatic Hernia (CDH). Pediatr Res 68 (Suppl 1), 264–265 (2010). https://doi.org/10.1203/00006450-201011001-00517
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DOI: https://doi.org/10.1203/00006450-201011001-00517
