580 Hypothermia Treatment Prolongs the Possible Time to Recovery of Aeeg to Predict Normal Cognitive and Motor Outcome

Abstract

BACKGROUND AND Aims: This study aims to investigate the correlation between amplitudeintegrated EEG (aEEG) and outcome at 24 months in full-term infants treated with systemic hypothermia after perinatal asphyxia and moderate/severe hypoxic-ischemic encephalopathy (HIE).

Methods: In 2007, 21 infants with HIE were treated with systemic hypothermia (body temperature 33- 34°C for 72 hours) using a Thecoterm® device aEEG was continuously monitored and the level of encephalopathy assessed. Follow-up of cognitive, language and motor function according to Bayley III Scales (BSID) was carried out at 24 months of age.

Results: All 12 children with normal BSID normalized their aEEG background pattern within 48 hours. Adverse outcome, defined as cerebral palsy (CP)/frank neurological or cognitive abnormalities/ death, was seen only among infants with persisting pathological aEEG at and beyond 24 hours. 5 children were lost to follow up.

Table 1

Table 1

Conclusion: With the exception of 2 children, a normalization of aEEG within 48 hours was associated with good outcome at 24 months of age. The 2 children who developed CP showed a normalization of aEEG at 24 and 48 hours respectively. Further follow-up is necessary to fully evaluate cognitive functions.

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