Abstract
Background and Objective
To investigate the relation of early brain activity with structural (growth of the cortex and cerebellum) and white matter microstructural brain development.
Methods
A total of 33 preterm neonates (gestational age 26±1 weeks) without major brain abnormalities were continuously monitored with electroencephalography during the first 48 h of life. Rate of spontaneous activity transients per minute (SAT rate) and inter-SAT interval (ISI) in seconds per minute were calculated. Infants underwent brain magnetic resonance imaging ∼30 (mean 30.5; min: 29.3–max: 32.0) and 40 (41.1; 40.0–41.8) weeks of postmenstrual age. Increase in cerebellar volume, cortical gray matter volume, gyrification index, fractional anisotropy (FA) of posterior limb of the internal capsule, and corpus callosum (CC) were measured.
Results
SAT rate was positively associated with cerebellar growth (P=0.01), volumetric growth of the cortex (P=0.027), increase in gyrification (P=0.043), and increase in FA of the CC (P=0.037). ISI was negatively associated with cerebellar growth (P=0.002).
Conclusions
Increased early brain activity is associated with cerebellar and cortical growth structures with rapid development during preterm life. Higher brain activity is related to FA microstructural changes in the CC, a region responsible for interhemispheric connections. This study underlines the importance of brain activity for microstructural brain development.
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Acknowledgements
This work includes infants participating in the Neobrain study (LSHM-CT-2006-036534). The first draft of the manuscript has been written by M.L.T. and N.H.P.C. Part of this study was presented as an abstract at the 5th Congress of the European Academy of Paediatric Societies (EAPS) 17–21 October 2014, Barcelona (Spain), PS47.
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The research of A.L. is supported by VIDI Grant 639.072.411 from the Netherlands Organization for Scientific Research (NWO).
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Tataranno, M., Claessens, N., Moeskops, P. et al. Changes in brain morphology and microstructure in relation to early brain activity in extremely preterm infants. Pediatr Res 83, 834–842 (2018). https://doi.org/10.1038/pr.2017.314
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DOI: https://doi.org/10.1038/pr.2017.314
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