Fig. 1: Inhibitory receptor expression in immune cells. | Experimental & Molecular Medicine

Fig. 1: Inhibitory receptor expression in immune cells.

From: The role of coinhibitory receptor-expressing non-T cells in inflammation and immunity: unsung heroes or peripheral players?

Fig. 1: Inhibitory receptor expression in immune cells.The alternative text for this image may have been generated using AI.

a This schematic illustrates the ligand–receptor interactions and downstream immunoregulatory effects of five inhibitory receptors: PD1, CTLA4, Lag3, Tim3 and TIGIT. Each receptor interacts with one or more ligands and transduces intracellular signals that lead to diverse function outcomes in a variety of cell types. The question marks indicate that the precises signaling mechanisms or intermediates remain unknown. The black text denotes effects in T cells. The gray text denotes effects in non-T cells (DCs, macrophages, B cells, mast cells and ILCs). The asterisk indicates that the effect is shared between both populations. The pound symbol (#) indicates that the effect is specific to regulatory T cells. Ab prod, antibody production; FAO, fatty acid oxidation; ROS, reactive oxygen species. b This diagram illustrates the expression patterns of inhibitory receptors—PD1, CTLA4, Lag3, Tim3 and TIGIT—across immune cell types, T cells, DCs, macrophages, microglia, B cells, mast cells and ILCs.

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