Fig. 1: Hypoxia response pathway.
From: EGLN1 (PHD2) role in tumor microenvironment: insights for therapeutic targeting
In normoxia, the PHD enzyme hydroxylates the HIF-α subunit, leading to recognition by pVHL and degradation by the proteasome. In hypoxia, PHD enzyme is inactive and the HIF-α subunit is stabilized, enters the nucleus, dimerizes with HIF-β subunit and activates the transcription of hypoxic response genes. Created in https://BioRender.com.
