Table 3 Top methylation quantitative trait loci significantly associated with CpG sites from epigenome wide association study of BMI or GWG in gestational week 28 ± 2, and their associated phenotypes in published genome wide association studies (p < 0.001).
CpG | Ancestry | mQTLs | Number of variants | Top gene variant | Chromosome | Associated phenotypes | Kolonne2 | Kolonne3 |
|---|---|---|---|---|---|---|---|---|
Phenotype | Direction | p-value | ||||||
cg02786370 | European | Cis | 231 | rs7694454 | 4 | Basophile count (PMID: 27863252) | − | 4.33e-04 |
Trans | 13 | rs9472010 | 6 | Coronary artery disease (PMID: 29212778) | + | 7.10e-04 | ||
68 | rs10119911 | 9 | BMI (PMID: 25673413, 26426971). | − | 5.16e-04 | |||
Hemoglobin concentration (PMID: 27863252) | + | 7.21e-04 | ||||||
Allergic disease (PMID: 29083406) | − | 2.39e-05 | ||||||
Asthma (PMID: 29273806) | − | 5.98e-04 | ||||||
cg164733643 | European | Cis | 418 | rs12059241 | 1 |
