Fig. 3 | International Journal of Oral Science

Fig. 3

From: Single-cell transcriptional atlas reveals distinct immune-chondrocyte crosstalk mechanisms in temporomandibular joint osteoarthritis induced by different types of occlusal disorder

Fig. 3

Comparison of cell composition and pseudotime developmental trajectory of the chondrocytes between healthy and TMJOA condyles. a Co-immunofluorescence staining of the condyle for the ‘fibrotic chondrocytes’ marker ABI3BP (green) and the ‘IA chondrocytes’ marker NOS2 (red). Scale bar: 50 μm for the left panels, 20 μm for the right panels. b Co-immunofluorescence staining of the condyle for Collagen-X (COL10, green), MMP13 (red) and osteocalcin (OCN, purple). Scale bar: 50 μm for the low-power field, 20 μm for the high-power field. c Bar plot showing the proportion of chondrocytes subtypes in Ctrl, APC, and UAC groups, respectively. Visualization of cell clusters in scRNA-seq analysis of ctrl, APC, and UAC chondrocytes subtypes by UMAP. d Pseudo-time analysis of chondrocytes subtypes using Monocle3 of Ctrl, APC, and UAC groups

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