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  • Brief Communication
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Practice variation in therapeutic hypothermia for hypoxic ischemic encephalopathy among neonates with congenital heart disease in the United States

Journal of Perinatology volume 45, pages 265–267 (2025)Cite this article

Subjects

To the Editor:

Therapeutic hypothermia (TH) is the current standard of care for full-term and near-term neonates with moderate or severe hypoxic ischemic encephalopathy (HIE) [1, 2]. Infants with congenital heart disease (CHD) can also suffer perinatal hypoxic insults that lead to neonatal encephalopathy. As such, TH for HIE (TH–HIE) has recently been utilized successfully in neonates with ductal-dependent CHD with favorable short-term neurological outcomes [3]. However, there is considerable variability with recognition and implementation of TH–HIE in neonates with CHD [4]. Accordingly, the objective of this study was to examine institutional practices around the application of TH–HIE in neonates with CHD in selected centers in North America.

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Fig. 1: Bar graphs depicting survey responses.

References

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Acknowledgements

The authors extend their heartfelt gratitude to member sites from the Pediatric Cardiac Critical Care Consortium and the Children’s Hospitals Neonatal Consortium that participated in the survey. We would like to acknowledge ST, DKB and DM of the Pediatric Cardiac Critical Care Consortium for their valuable input for this study. Beverly Brozanski, Jacquelyn Evans, Theresa Grover, Karna Murthy, Michael Padula, Eugenia Pallotto, Anthony Piazza, Kristina Reber and Billie Short and ex-officio David Durand, Francine Dykes, Jeanette Asselin, are executive members of the Children’s Hospitals Neonatal Consortium, Inc., who developed and manage the CHND (thechnc.org). For more information, please contact: exec@thechnc.org.

Author information

Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, Arkansas Children’s Hospital, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Vonita Chawla

  2. Division of Neonatology, Department of Pediatrics, Cleveland Clinic Children’s Hospital, Case Western Reserve University, Cleveland, OH, USA

    Allison M. Peluso

  3. Division of Neonatology, Department of Pediatrics, Nationwide Children’s Hospital, The Ohio State University, Columbus, OH, USA

    Molly K. Ball

  4. Division of Cardiology, Department of Pediatrics, Benioff Children’s Hospital, University of California San Francisco, San Francisco, CA, USA

    Sarah Tabbutt

  5. Division of Pediatric Critical Care, Department of Pediatrics, Primary Children’s Hospital, University of Utah, Salt Lake City, UT, USA

    David K. Bailly

  6. Division of Cardiology, Department of Pediatrics, Rady Children’s Hospital, University of California San Diego, San Diego, CA, USA

    Dana Mueller

  7. Division of Neonatology, Department of Pediatrics, St. Louis Children’s Hospital, Washington University School of Medicine, St. Louis, MO, USA

    Rakesh Rao

  8. Division of Neonatology, Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA

    Philip T. Levy

  9. Children’s Healthcare of Atlanta – Egleston, Atlanta, GA, USA

    Anthony Piazza

  10. Children’s Healthcare of Atlanta – Scottish Rite, Atlanta, GA, USA

    Gregory Sysyn

  11. Dell Children’s Medical Center, Austin, TX, USA

    Ashley Lucke & Molly Pont

  12. Children’s of Alabama, Birmingham, AL, USA

    Allison Black & Carl Coghill

  13. Boston Children’s Hospital, Boston, MA, USA

    Marth Sola Visner

  14. Levine Children’s Hospital, Charlotte, NC, USA

    Eugenia Pallotto

  15. Ann & Robert H. Lurie Children’s Hospital, Chicago, IL, USA

    Karna Murthy & Gustave Falciglia

  16. Cincinnati Children’s Hospital, Cincinnati, OH, USA

    Beth Haberman

  17. Cleveland Clinic, Cleveland, OH, USA

    Ceyda Acun

  18. Nationwide Children’s Hospital, Columbus, OH, USA

    Thomas Bartman

  19. Children’s Medical Center, Dallas, TX, USA

    Sushmita Yallapragada & Lina Chalak

  20. Children’s Hospital Colorado, Denver, CO, USA

    Danielle Smith & Stephanie Bourque

  21. Children’s Hospital Michigan, Detroit, MI, USA

    Girija Natarajan

  22. Cook Children’s Healthcare System, Fort Worth, TX, USA

    Annie Chi & Yvette Johnson

  23. Connecticut Children’s Medical Center, Hartford, CT, USA

    Annmarie Gotiolo

  24. Texas Children’s Hospital, Houston, TX, USA

    Lakshmi Katarkan & Kristina Reber

  25. Riley Children’s Health, Indianapolis, IN, USA

    Rebecca Rose

  26. University of Iowa Stead Family Children’s Hospital, Iowa City, IA, USA

    Julie Lindower

  27. The Children’s Mercy Hospital, Kansas City, MO, USA

    Julie Weiner

  28. Arkansas Children’s Hospital, Little Rock, AR, USA

    Laura Carroll

  29. Los Angeles Children’s Hospital, Los Angeles, CA, USA

    Rachel Chapman

  30. American Family Children’s Hospital, Madison, WI, USA

    Nina Menda

  31. Le Bonheur Children’s Hospital, Memphis, TN, USA

    Mark Weems

  32. Children’s Minnesota Hospital, Minneapolis, MN, USA

    Ann Downey

  33. Wisconsin Children’s Hospital, Milwaukee, WI, USA

    Joanne Lagatta

  34. UCSF Benioff Children’s Hospital, Oakland, CA, USA

    Priscilla Joe

  35. Oklahoma Children’s Hospital, Oklahoma City, OK, USA

    Trent Tipple & Patricia Williams

  36. Omaha Children’s Hospital, Omaha, NE, USA

    Nicole Birge

  37. Children’s Hospital of Orange County, Orange County, CA, USA

    Michel Mikhael

  38. AdventHealth for Children, Orlando, FL, USA

    Narendra Dereddy & Rajan Wadhawan

  39. Nemours Children’s Hospital, Orlando, FL, USA

    Aaron Weiss

  40. Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Michael Padula

  41. St. Christopher’s Hospital for Children, Philadelphia, PA, USA

    Vilarmis Quinones

  42. Phoenix Children’s Hospital, Phoenix, AZ, USA

    Pam Griffiths

  43. Pittsburgh Children’s Hospital, Pittsburgh, PA, USA

    Toby Yanowitz

  44. Mayo Clinic Children’s Center, Rochester, MN, USA

    Ellen Bendel-Stenzel

  45. Primary Children’s Hospital, Salt Lake City, UT, USA

    Con Yee Ling

  46. Rady Children’s Hospital, San Diego, CA, USA

    Mark Speziale

  47. Seattle Children’s Hospital, Seattle, WA, USA

    Robert DiGeronimo & Elizabeth Jacobsen

  48. St. Louis Children’s Hospital, St. Louis, MO, USA

    Beverly Brozanski & Rakesh Rao

  49. Children’s Minnesota Hospital, St. Paul, MN, USA

    Ann Downey

  50. All Children’s Hospital, St. Petersburg, FL, USA

    Linda Van Marter

  51. The Hospital for Sick Children, Toronto, ON, Canada

    Kyong-Soon Lee

  52. Children’s National Hospital, Washington, DC, USA

    Billie Lou Short

  53. Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA

    Kevin Sullivan

  54. Brenner Children’s Hospital, Winston-Salem, NC, USA

    Cherrie Welch

Authors
  1. Vonita Chawla
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  2. Allison M. Peluso
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  3. Molly K. Ball
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  4. Sarah Tabbutt
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  5. David K. Bailly
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  6. Dana Mueller
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  7. Rakesh Rao
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  8. Philip T. Levy
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Consortia

On Behalf of the Children’s Hospitals Neonatal Consortium Cardiac Focus Group and the Pediatric Cardiac Critical Care Consortium

  • Anthony Piazza
  • , Gregory Sysyn
  • , Ashley Lucke
  • , Molly Pont
  • , Allison Black
  • , Carl Coghill
  • , Marth Sola Visner
  • , Eugenia Pallotto
  • , Karna Murthy
  • , Gustave Falciglia
  • , Beth Haberman
  • , Ceyda Acun
  • , Thomas Bartman
  • , Sushmita Yallapragada
  • , Lina Chalak
  • , Danielle Smith
  • , Stephanie Bourque
  • , Girija Natarajan
  • , Annie Chi
  • , Yvette Johnson
  • , Annmarie Gotiolo
  • , Lakshmi Katarkan
  • , Kristina Reber
  • , Rebecca Rose
  • , Julie Lindower
  • , Julie Weiner
  • , Laura Carroll
  • , Rachel Chapman
  • , Nina Menda
  • , Mark Weems
  • , Ann Downey
  • , Joanne Lagatta
  • , Priscilla Joe
  • , Trent Tipple
  • , Patricia Williams
  • , Nicole Birge
  • , Michel Mikhael
  • , Narendra Dereddy
  • , Rajan Wadhawan
  • , Aaron Weiss
  • , Michael Padula
  • , Vilarmis Quinones
  • , Pam Griffiths
  • , Toby Yanowitz
  • , Ellen Bendel-Stenzel
  • , Con Yee Ling
  • , Mark Speziale
  • , Robert DiGeronimo
  • , Elizabeth Jacobsen
  • , Beverly Brozanski
  • , Rakesh Rao
  • , Ann Downey
  • , Linda Van Marter
  • , Kyong-Soon Lee
  • , Billie Lou Short
  • , Kevin Sullivan
  •  & Cherrie Welch

Contributions

VC, AMP, MKB, RR and PTL developed the project and designed the survey. VC, MKB and PTL drafted the manuscript. VC, AMP, MKB, ST, DKB, DM, RR and PTL critically reviewed, revised and approved the final version.

Corresponding author

Correspondence to Vonita Chawla.

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Competing interests

The authors declare no competing interests.

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Chawla, V., Peluso, A.M., Ball, M.K. et al. Practice variation in therapeutic hypothermia for hypoxic ischemic encephalopathy among neonates with congenital heart disease in the United States. J Perinatol 45, 265–267 (2025). https://doi.org/10.1038/s41372-024-02173-1

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  • DOI: https://doi.org/10.1038/s41372-024-02173-1

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