Table 2 Clinical and ultrasound data of stable preterm infants in the early and late NICU admission period.1.
Early NICU period (day 3 to 21) | Late NICU period (34 to 37 weeks cGA) | p-value | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
percentile | 10 | 25 | 50 | 75 | 90 | 10 | 25 | 50 | 75 | 90 | ||
HR | bpm | 146 | 152 | 162 | 172 | 179 | 147 | 153 | 164 | 171 | 179 | 0.477 |
SBP | mmHg | 52 | 55 | 61 | 66 | 71 | 63 | 72 | 76 | 81 | 86 | <0.001 |
DBP | mmHg | 29 | 32 | 36 | 41 | 44 | 33 | 35 | 40 | 44 | 50 | <0.001 |
Diastolic function | ||||||||||||
LAvol | ml/kg | 0.58 | 0.71 | 0.86 | 1.03 | 1.24 | 0.72 | 0.83 | 1.00 | 1.14 | 1.33 | 0.001 |
E | cm/s | 33 | 36 | 41 | 48 | 55 | 57 | 70 | 80 | 92 | 97 | <0.001 |
DT | msec | 57 | 72 | 83 | 95 | 108 | 57 | 82 | 92 | 113 | 130 | 0.021 |
DR | m/s2 | 3.9 | 4.4 | 5.6 | 6.3 | 7.3 | 6.7 | 7.3 | 8.5 | 9.4 | 11.1 | <0.001 |
A | cm/s | 43 | 51 | 56 | 62 | 70 | 76 | 83 | 91 | 104 | 116 | <0.001 |
EA ratio | 0.61 | 0.67 | 0.73 | 0.82 | 0.90 | 0.67 | 0.84 | 0.91 | 0.96 | 1.05 | <0.001 | |
MV vti | cm | 4.4 | 5.2 | 5.7 | 6.6 | 7.9 | 7.5 | 8.7 | 10.0 | 11.0 | 12.1 | <0.001 |
e' | cm/s | 2.8 | 3.1 | 3.4 | 3.8 | 4.6 | 4.0 | 4.8 | 5.6 | 6.3 | 6.7 | <0.001 |
a' | cm/s | 4.8 | 5.5 | 5.9 | 6.8 | 7.5 | 6.6 | 7.4 | 8.4 | 9.7 | 10.9 | <0.001 |
ea ratio | 0.44 | 0.51 | 0.58 | 0.65 | 0.71 | 0.50 | 0.59 | 0.64 | 0.73 | 0.86 | <0.001 | |
Ee ratio | 9.2 | 10.6 | 11.9 | 13.6 | 15.4 | 10.5 | 12.5 | 14.0 | 17.8 | 21.0 | <0.001 | |
LASR | % | 26 | 30 | 34 | 39 | 43 | 26 | 31 | 36 | 40 | 44 | 0.054 |
SRE | s-1 | 1.57 | 1.84 | 2.17 | 2.44 | 2.79 | 1.48 | 2.04 | 2.40 | 2.95 | 3.35 | 0.036 |
E/SRE ratio | 14.1 | 16.1 | 18.8 | 23.5 | 26.4 | 22.8 | 26.4 | 34.5 | 40.5 | 52.7 | <0.001 | |
Cardiac cycle events | ||||||||||||
St | msec | 164 | 178 | 195 | 204 | 215 | 179 | 201 | 208 | 215 | 223 | <0.001 |
Dt | msec | 148 | 160 | 177 | 193 | 209 | 146 | 157 | 175 | 193 | 199 | 0.359 |
St/Dt ratio | 0.91 | 0.99 | 1.11 | 1.20 | 1.30 | 1.06 | 1.12 | 1.18 | 1.26 | 1.33 | <0.001 | |
IVRT | msec | 35 | 40 | 45 | 55 | 58 | 38 | 40 | 44 | 51 | 55 | 0.777 |
Cardiac shape and size | ||||||||||||
EDV | ml/kg | 1.42 | 1.66 | 1.83 | 2.07 | 2.34 | 1.48 | 1.62 | 1.94 | 2.17 | 2.36 | 0.263 |
ESV | ml/kg | 0.50 | 0.56 | 0.71 | 0.86 | 0.99 | 0.61 | 0.70 | 0.82 | 0.97 | 1.14 | 0.002 |
LVL | mm | 19.3 | 20.9 | 22.1 | 23.4 | 24.5 | 25.4 | 26.7 | 28.7 | 29.3 | 30.6 | <0.001 |
LVW | mm | 8.7 | 10.2 | 11.4 | 12.7 | 13.6 | 14.5 | 15.3 | 16.6 | 17.4 | 18.1 | <0.001 |
LV SI | 1.68 | 1.75 | 1.89 | 2.06 | 2.22 | 1.54 | 1.61 | 1.69 | 1.83 | 1.95 | <0.001 | |
LV mass | gr/m2 | 22.9 | 25.8 | 28.7 | 32.3 | 35.1 | 29.0 | 31.2 | 36.1 | 39.5 | 43.0 | <0.001 |
LV M/V | 1.22 | 1.44 | 1.62 | 1.82 | 2.03 | 1.00 | 1.28 | 1.43 | 1.63 | 1.82 | 0.001 | |
Systolic function | ||||||||||||
EF | % | 49 | 54 | 62 | 68 | 72 | 46 | 49 | 55 | 60 | 67 | 0.003 |
LV SV | ml/kg | 0.79 | 0.90 | 1.13 | 1.31 | 1.53 | 0.72 | 0.87 | 1.03 | 1.23 | 1.44 | 0.393 |
s' | cm/s | 3.3 | 3.7 | 4.0 | 4.3 | 4.7 | 4.4 | 4.8 | 5.5 | 6.0 | 6.5 | <0.001 |
SL | % | 15.3 | 16.1 | 17.2 | 19.0 | 21.1 | 17.4 | 18.5 | 19.4 | 21.2 | 22.3 | <0.001 |