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Neighborhood socioeconomic disadvantage and chorioamnionitis

Journal of Perinatology (2025)Cite this article

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Chorioamnionitis affects 3–5% of deliveries at term and is a significant source of maternal and neonatal morbidity and mortality [1]. Prior studies examined the role of individual-level social determinants of health (iSDOH), including lack of healthcare access and minoritized race and ethnicity, as risk factors for chorioamnionitis [2].

Recent data highlight that adverse neighborhood-level SDOH (nSDOH) are associated with adverse pregnancy outcomes [3], as well as infectious morbidity outside of pregnancy [4]. Data in pregnancy suggest an association between nSDOH and vaginal microbiota [5], as well as an association between the vaginal microbiota and risk of chorioamnionitis [6]. However, to date, studies have not examined the relationship between nSDOH and perinatal infectious morbidity. Whether nSDOH are associated with chorioamnionitis remains to be investigated and could have implications for structural interventions to address disparities in perinatal infectious morbidity.

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References

  1. Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD. Chorioamnionitis and risk for maternal and neonatal sepsis: a systematic review and meta-analysis. Obstet Gynecol. 2021;137:1007–22. https://doi.org/10.1097/aog.0000000000004377.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Gomez Slagle HB, Hoffman MK, Fonge YN, Caplan R, Sciscione AC. Incremental risk of clinical chorioamnionitis associated with cervical examination. Am J Obstet Gynecol MFM. 2022;4:100524. https://doi.org/10.1016/j.ajogmf.2021.100524.

    Article  PubMed  CAS  Google Scholar 

  3. Field C, Wang XY, Costantine MM, Landon MB, Grobman WA, Venkatesh KK. Social determinants of health and diabetes in pregnancy. Am J Perinatol. 2024. https://doi.org/10.1055/a-2405-2409.

  4. Sood G, Dougherty G, Martin J, Beranek E, Landrum BM, Qasba S, et al. Is neighborhood deprivation index a risk factor for Staphylococcus aureus infections? Am J Infect Control. 2023;51:1314–20. https://doi.org/10.1016/j.ajic.2023.07.001.

    Article  PubMed  CAS  Google Scholar 

  5. Dixon M, Dunlop AL, Corwin EJ, Kramer MR. Joint effects of individual socioeconomic status and residential neighborhood context on vaginal microbiome composition. Front Public Health. 2023;11:1029741. https://doi.org/10.3389/fpubh.2023.1029741.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Guo X, Hong X, Qian H, Qiao D, Wang B, Yu H. Relationship between vaginal microbiota and chorioamnionitis: a prospective cohort study. Microb Pathog. 2024;186:106458. https://doi.org/10.1016/j.micpath.2023.106458.

    Article  PubMed  Google Scholar 

  7. Kind AJH, Buckingham WR. Making neighborhood-disadvantage metrics accessible - the neighborhood atlas. N Engl J Med. 2018;378:2456–8. https://doi.org/10.1056/NEJMp1802313.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Ananth CV, Schisterman EF. Confounding, causality, and confusion: the role of intermediate variables in interpreting observational studies in obstetrics. Am J Obstet Gynecol. 2017;217:167–75. https://doi.org/10.1016/j.ajog.2017.04.016.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Jasthi DL, Lappen JR, Garber S, Kennedy S, McCarther N, Nagle-Yang S, et al. Associations between adverse childhood experiences and obstetrical outcomes in a predominantly Black-identifying and low-income pregnant population. Am J Obstet Gynecol MFM. 2023;5:101008. https://doi.org/10.1016/j.ajogmf.2023.101008.

    Article  PubMed  Google Scholar 

  10. Pantell MS, Baer RJ, Torres JM, Felder JN, Manchikanti Gomaz A, Chambers B, et al. Associations between unstable housing, obstetric outcomes, and perinatal health care utilization. Am J Obstet Gynecol MFM. 2019;1:100053. https://doi.org/10.1016/j.ajogmf.2019.100053.

    Article  PubMed  Google Scholar 

  11. Sullivan BA, Doshi A, Chernyavskiy P, Husain A, Binai A, Sahni R, et al. Neighborhood deprivation and association with neonatal intensive care unit mortality and morbidity for extremely premature infants. JAMA Netw Open. 2023;6:e2311761. https://doi.org/10.1001/jamanetworkopen.2023.11761.

    Article  PubMed  PubMed Central  Google Scholar 

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Funding

Support for the nuMoM2b study was provided by grant funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development: RTI International grant U10 HD063036; Case Western Reserve University grant U10 HD063072; Columbia University grant U10 HD063047; Indiana University grant U10 HD063037; University of Pittsburgh grant U10HD063041; Northwestern University grant U10 HD063020; University of California, Irvine grant U10 HD063046; University of Pennsylvania grant U10 HD063048; and University of Utah grant U10 HD063053. In addition, support was provided by respective Clinical and Translational Science Institutes to Indiana University (grant UL1TR001108) and University of California, Irvine (grant UL1TR000153). Dr. Venkatesh was supported by the Care Innovation and Community Improvement Program at The Ohio State University.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH, USA

    Christine Field, Jiqiang Wu & Kartik K. Venkatesh

  2. Department of Obstetrics and Gynecology, Brown University, Providence, RI, USA

    William A. Grobman

  3. RTI International, Durham, NC, USA

    Becky McNeil

  4. Department of Obstetrics and Gynecology, Indiana University, Corydon, IN, USA

    David M. Haas

  5. Department of Obstetrics and Gynecology, Case Western Reserve University, Cleveland, OH, USA

    Jessica L. Pippen

  6. Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, PA, USA

    Hyagriv N. Simhan

  7. Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA

    Uma M. Reddy

  8. Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA

    Robert M. Silver

  9. Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA, USA

    George R. Saade

  10. Department of Obstetrics and Gynecology, University of California, Irvine, School of Medicine, Orange, CA, USA

    Judith Chung

  11. Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA

    Lisa Levine

  12. Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL, USA

    Lynn M. Yee

Authors
  1. Christine Field
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  2. William A. Grobman
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  3. Jiqiang Wu
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  4. Becky McNeil
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  5. David M. Haas
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  6. Jessica L. Pippen
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  7. Hyagriv N. Simhan
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  8. Uma M. Reddy
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  9. Robert M. Silver
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  10. George R. Saade
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  11. Judith Chung
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  12. Lisa Levine
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  13. Lynn M. Yee
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  14. Kartik K. Venkatesh
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Contributions

CF, KVV and WAG contributed to conceptualization, methodology and writing (original draft preparation and review/editing). JW contributed to methodology, formal analysis and writing (original draft preparation and review/editing). BN, DMH, JLP, HNS, UMR, RMS, GRS, JC, LL and LMY contributed to conceptualization and writing (review/editing).

Corresponding author

Correspondence to Christine Field.

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The authors declare no competing interests.

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Field, C., Grobman, W.A., Wu, J. et al. Neighborhood socioeconomic disadvantage and chorioamnionitis. J Perinatol (2025). https://doi.org/10.1038/s41372-025-02510-y

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