Fig. 1: Causes of PPHN. | Journal of Perinatology

Fig. 1: Causes of PPHN.

From: Phenotyping persistent pulmonary hypertension of the newborn: recognition of its persistence across world symposium on pulmonary hypertension classifications

Fig. 1: Causes of PPHN.The alternative text for this image may have been generated using AI.

Causes of Persistent Pulmonary Hypertension of the Newborn: Etiologies of persistent pulmonary hypertension of the newborn (PPHN) based on pulmonary vascular development divided into disorders that lead to an increase in pulmonary vascular resistance (PVR): normal lung parenchyma with maladaptive pulmonary vasculature; pulmonary vascular remodeling with maldevelopment of the pulmonary vasculature and abnormal lung parenchyma; and (2) disorders that affect pulmonary blood flow (PBF) and pulmonary capillary wedge pressure (PCWP) from increased pulmonary venous congestion and cardiac dysfunction. ABCA3 ATP-binding cassette subfamily A member 3, AP aortopulmonary, ASD atrial septal defect, PDA patent ductus arteriosus, AVM arteriovenous malformation, CDH congenital diaphragm hernia, CoA coenzyme A, IDM infants of diabetic mothers, NSAID nonsteroidal ant-inflammatory drug, PPROM prolonged preterm premature rupture of membrane, SPD surfactant protein deficiency, SSRI selective serotonin reuptake inhibitor, VSD ventricular septal defect.

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