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Chronic lymphocytic leukemia

Circ-RPL15: a plasma circular RNA as novel oncogenic driver to promote progression of chronic lymphocytic leukemia

Leukemia volume 34, pages 919–923 (2020)Cite this article

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Chronic lymphocytic leukemia (CLL), the most frequently occurring leukemia in western countries, is a heterogeneous disease and characterized by the accumulation of monoclonal B lymphocytes in blood, bone marrow, and lymphoid tissues [1]. Although diagnosis and therapy have been developing, several high-risk features for CLL patients have been identified [2]. Immunoglobulin heavy-chain variable region (IGHV) has been confirmed as a valuable independent prognostic factor [3]. However, it is of vital importance to explore alternative markers because of limitation of the detection of IGHV mutation in routine laboratory diagnosis process.

Recently, accumulating evidence reveals that non-coding RNAs including circRNAs may exert vital biological functions and can be used as new biomarkers for diagnosis as well as provide promising therapeutic approaches for various solid tumors [4, 5] and leukemias [6, 7]. CircRNAs which are characterized by covalently closed continuous loops without 5′ to 3′ polarity and polyadenylated tail were proved to function as competing endogenous RNAs to interact with microRNAs (miRNAs) and regulate targeted genes expression [8, 9]. However, little is known about the roles of circRNAs in CLL.

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References

  1. Hallek M. Chronic lymphocytic leukemia: 2017 update on diagnosis, risk stratification, and treatment. Am J Hematol. 2017;92:946–65.

    Article  CAS  Google Scholar 

  2. Nadeu F, Delgado J, Royo C, Baumann T, Stankovic T, Pinyol M, et al. Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia. Blood. 2016;127:2122–30.

    Article  CAS  Google Scholar 

  3. Crombie J, Davids MS. IGHV mutational status testing in chronic lymphocytic leukemia. Am J Hematol. 2017;92:1393–7.

    Article  CAS  Google Scholar 

  4. Du WW, Yang W, Liu E, Yang Z, Dhaliwal P, Yang BB. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res. 2016;44:2846–58.

    Article  Google Scholar 

  5. Tang W, Fu K, Sun H, Rong D, Wang H, Cao H. CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer. Mol Cancer. 2018;17:137.

    Article  Google Scholar 

  6. Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV, Berry K, Naldini MM, et al. Oncogenic role of fusion-circRNAs derived from cancer-associated chromosomal translocations. Cell. 2016;165:289–302.

    Article  CAS  Google Scholar 

  7. Hirsch S, Blatte TJ, Grasedieck S, Cocciardi S, Rouhi A, Jongen-Lavrencic M, et al. Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia. Haematologica. 2017;102:2039–47.

    Article  CAS  Google Scholar 

  8. Han D, Li J, Wang H, Su X, Hou J, Gu Y, et al. Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. Hepatology. 2017;66:1151–64.

    Article  CAS  Google Scholar 

  9. Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B, et al. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nat Commun. 2016;7:11215.

    Article  CAS  Google Scholar 

  10. Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495:384–8.

    Article  CAS  Google Scholar 

  11. Wang M, Kluin P, Rosati S, Luinge M, Daenen S, Visser L. Raf-1 is overexpressed in chronic lymphocytic leukemia and promotes cell survival by phosphorylation of ERK and Bad. Blood. 2008;112:3120.

    Google Scholar 

  12. Messmer D, Fecteau JF, O’Hayre M, Bharati IS, Handel TM, Kipps TJ. Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib. Blood. 2011;117:882–9.

    Article  CAS  Google Scholar 

  13. Panka DJ, Atkins MB, Mier JW. Targeting the mitogen-activated protein kinase pathway in the treatment of malignant melanoma. Clin Cancer Res. 2006;12:2371s–2375s.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This study was supported by National Natural Science Foundation of China (Grant nos. 81700155, 81370657, 81600130, 81770166, 81720108002, 81700114, and 81600078), Jiangsu Province’s Medical Elite Programme (ZDRCA2016022), Jiangsu Provincial Special Program of Medical Science (BE2017751), and National Science and Technology Major Project (2018ZX09734007).

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  1. These authors contributed equally: Zijuan Wu, Handong Sun, Wenjie Liu

Authors and Affiliations

  1. Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China

    Zijuan Wu, Wenjie Liu, Huayuan Zhu, Jianxin Fu, Lei Fan, Li Wang, Wei Xu, Jianyong Li & Hui Jin

  2. Key Laboratory of Hematology of Nanjing Medical University, 210029, Nanjing, China

    Zijuan Wu, Wenjie Liu, Huayuan Zhu, Jianxin Fu, Lei Fan, Li Wang, Wei Xu, Jianyong Li & Hui Jin

  3. Collaborative Innovation Center for Cancer Personalized Medicine, 210029, Nanjing, China

    Zijuan Wu, Wenjie Liu, Huayuan Zhu, Jianxin Fu, Lei Fan, Li Wang, Wei Xu, Jianyong Li & Hui Jin

  4. Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China

    Handong Sun & Chuang Yang

  5. Department of Hematology, Qilu hospital, Shandong University, 250012, Jinan, China

    Yanfeng Liu

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  1. Zijuan Wu
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Correspondence to Jianyong Li or Hui Jin.

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Wu, Z., Sun, H., Liu, W. et al. Circ-RPL15: a plasma circular RNA as novel oncogenic driver to promote progression of chronic lymphocytic leukemia. Leukemia 34, 919–923 (2020). https://doi.org/10.1038/s41375-019-0594-6

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