Table 1 Demographics and key variables.
From: Functional variant rs9344 at 11q13.3 regulates CCND1 expression in multiple myeloma with t(11;14)
Variable | CoMMpass (n = 698) | Mayo (n = 661) | p value |
|---|---|---|---|
n (%) | mean ± sd (range) | n (%) | mean ± sd (range) | ||
Age (years) | |||
62.87 ± 10.79 (27–93) | 62.80 ± 10.35 (31–92) | 0.91a | |
Sex | |||
Female | 281 (40.26) | 297 (44.93) | |
Male | 417 (59.74) | 364 (55.07) | 0.09b |
Race | |||
White | 454 (65.04) | 598 (90.47) | |
Black | 91 (13.04) | 23 (3.48) | |
Asian | 11 (1.58) | 9 (1.36) | |
Other | 30 (4.30) | 16 (2.42) | |
Unknown | 112 (16.05) | 15 (2.27) | <0.001b |
Ethnicity | |||
Non-Hispanic White | 404 (57.88) | 505 (76.40) | |
Non-Hispanic Black | 90 (12.89) | 15 (2.27) | |
Other | 204 (29.23) | 141 (21.33) | <0.001b |
Cytogenetic abnormalities | |||
Hyperdiploidy | 379 (54.30) | 311 (47.05) | |
t(11;14) | 135 (19.34) | 139 (21.03) | |
t(4;14) | 83 (11.89) | 57 (8.62) | |
t(14;16) | 30 (4.30) | 20 (3.03) | |
t(6;14) | 10 (1.43) | 8 (1.21) | |
t(14;20) | 8 (1.15) | 9 (1.36) | |
Unknown | 53 (7.59) | 117 (17.7) | <0.001b |
rs9344 genotype | |||
AA | 116 (16.62) | 122 (18.46) | |
AG | 317 (45.42) | 298 (45.08) | |
GG | 265 (37.97) | 241 (36.46) | 0.65b |
rs9344 in t(11;14)c | |||
A allele | 23 (17.04) | 26 (18.71) | |
G allele | 112 (82.96) | 113 (81.29) | 0.96b |
CCND1 expression (TPM) | |||
Overall | 42.81 ± 97.61 | 26.71 ± 59.64 | |
t(11;14) | 200.01 ± 134.78 | 118.58 ± 78.82 | |
Non-t(11;14) | 5.12 ± 11.26 | 2.25 ± 2.99 | - |
PAX5 expression (TPM) | |||
Overall | 0.12 ± 0.3 | 0.06 ± 0.09 | |
t(11;14) | 0.3 ± 0.38 | 0.11 ± 0.12 | |
Non-t(11;14) | 0.07 ± 0.27 | 0.04 ± 0.08 | - |
CD group in t(11;14) | |||
CD1 | 54 (40.00) | 56 (40.29) | 0.96 |
CD2a/b | 81 (60.00) | 83 (59.71) | |
Overall Survival (years)d | |||
Range | 0.022–10.18 | 0.003–30.81 | |
Median | 7.82 (6.61 – NA) | 7.77 (6.67–8.55) | 0.70e |
