Table 2 Effect of rs9344 genotype on CCND1 expression stratified by t(11;14) status.

From: Functional variant rs9344 at 11q13.3 regulates CCND1 expression in multiple myeloma with t(11;14)

t(11;14)

Gt.

CoMMpass

Mayo

Freq.

Coe. (95% CI)a

p valuea

Freq.

Coe. (95% CI)a

p valuea

No

AA

105

Ref.

Ā 

108

Ref.

Ā 

No

GG | AG

458

āˆ’3.56 (āˆ’16.44–9.32)

0.59

414

āˆ’0.53 (āˆ’8.23–7.18)

0.89

Yes

AA

11

162.13 (124.83–199.43)

9.0 × 10āˆ’17

14

100.58 (80.34–120.82)

4.3 × 10-21

Yes

GG | AG

124

195.58 (179.84–211.32)

4.1 × 10āˆ’95

125

117.48 (108.1–126.85)

3.5 × 10-95

  1. Gt. indicates genotype, Freq. indicates frequency, Coe. (95% CI) indicates coefficient (95% confidence interval) with a coefficient that is greater than zero indicates a positive relationship and a coefficient that is less than zero indicates a negative relationship.
  2. aderived from a generalized linear regression model normalized on age (continuous), sex (1 male, 0 female), and race (1 black, 0 non-black).