Table 3 Interaction of PAX5 expression with rs9344 genotype on CCND1 expression.

From: Functional variant rs9344 at 11q13.3 regulates CCND1 expression in multiple myeloma with t(11;14)

Term

CoMMpass

Mayo

Coe. (95% CI)a

p valuea

Coe. (95% CI)a

p valuea

Ā 

Genotype

PAX5 x AA

13.11 (āˆ’47.42–73.65)

0.67

79.2 (āˆ’77.85–236.24)

0.32

PAX5 x AG

90.57 (41.01–140.13)

0.00036

243.06 (143–343.13)

2.3 × 10āˆ’6

PAX5 x GG

210.5 (174.94–246.07)

1.3 × 10āˆ’28

146.06 (70.24–221.87)

0.00017

Ā 

Allele

PAX5 x A

2.97 (āˆ’53.27–59.2)

0.92

64.47 (āˆ’60.58–189.53)

0.31

PAX5 x G

178.45 (147–209.89)

1.3 × 10āˆ’26

188.4 (121.24–255.55)

5.2 × 10āˆ’8

  1. a derived from generalized linear regression model adjusted for age (continuous), sex (1 male, 0 female) and race (categorical); tumor stage was additionally adjusted for CoMMpass cohort. Only cases with t(11;14) were included in the analysis. Coe. (95% CI) indicates coefficient (95% confidence interval) with a coefficient that is greater than zero indicates a positive relationship and a coefficient that is less than zero indicates a negative relationship.