Fig. 5: CG1-bispecific antibody does not inhibit normal hematopoiesis.
From: Immunotherapy targeting a leader sequence cathepsin G-derived peptide
Healthy donor HLA-A2+Â bone marrow (BM) was cultured alone or co-cultured with peripheral blood mononuclear cells (PBMC) at increasing concentrations of CG1/A2xCD3 or control bispecific antibody. Cells were then resuspended in methylcellulose semi-solid matrix on low adhesion 6-well plates and co-cultured for 14 days. On day 14, colonies were counted and imaged using an inverted light microscope. Each group was cultured at least in duplicate and data represent four independent experiments. Cytarabine-treated BM was used as positive control.
