Table 2 Univariate analysis of factors predicting PFS in AYA and adult CML patients.

From: Somatic mutations and outcomes in chronic myeloid leukemia adolescent and young adults compared to children, adults, and BCR::ABL1-positive acute lymphoblastic leukemia

 

AYAs

Adults

Variable

HR

95% CI

p-value

HR

95% CI

p-value

High SOKAL

1.67

0.67-4.18

0.28

1.91

1.01-3.63

0.05

High EUTOS

1.94

0.77-4.89

0.16

3.4

1.66-6.98

0.001

High ELTS

0.84

0.2-3.56

0.81

7

3.29-14.89

<0.001

Nilotinib

0.23

0.05-0.98

0.05

2.12

0.51-8.79

0.30

ASXL1 at diagnosis

2.5

0.86-7.33

0.09

3.21

1.34-7.67

0.009

Any mutation at diagnosis

2.7

1.09-6.66

0.03

2.97

1.46-6.04

0.003

De novo nonBCR::ABL1 mutation

6.1

1.98-18.75

0.002

2.04

0.95-4.36

0.07

  1. The bold values mean that the analysed factor for PFS prediction was statistically significant.
  2. Univariate Cox Regression.
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