Fig. 2: Overview of recurrent genetic aberrations in the entire cohort and ATM-mutated cases. | Leukemia

Fig. 2: Overview of recurrent genetic aberrations in the entire cohort and ATM-mutated cases.

From: ATM aberrations in chronic lymphocytic leukemia: del(11q) rather than ATM mutations is an adverse-prognostic biomarker

Fig. 2

A Overview of all 3631 CLL cases included in the study, sorted by frequency of mutations in 10 recurrently mutated genes. B Oncoplot showing detected mutations in recurrently mutated genes, IGHV somatic hypermutation status and chromosomal aberrations in 246 ATM-mutated cases. C Co-occurrence of recurrent gene mutations and chromosomal aberrations in the entire cohort. Odds ratios (OR) and BH-adjusted p values derived from two-sided Fisher exact tests. OR 0–1 indicates a trend towards mutual exclusivity, OR > 1 indicates a trend towards co-occurrence. U-CLL, CLL with unmutated IGHV genes, M-CLL, CLL with mutated IGHV genes.

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