Fig. 5: In vivo comparison of ECM-microelectrodes and silicon microelectrodes.
From: Microfabricated intracortical extracellular matrix-microelectrodes for improving neural interfaces
a Immunohistochemical analysis of ECM-microelectrodes 2 mm below the cortical surface showed minimal glial reactivity and preservation of axonal integrity. b Corresponding analyses of silicon microelectrodes (Michigan M15 electrodes) at the same depth exhibits increased astrocytic reactivity and microglial density. c At 4 mm below the cortex, ECM-microelectrodes continue to display healthy axons and minimal glial reactivity. d Michigan electrodes at this depth yield reduced microglial infiltration but still induce hypertrophy of astrocytic processes. Electrode centers are indicated by asterisks. Scale bar = 50 µm
