Fig. 1: Schematic illustration of a fully packaged confocal endomicroscopic system for real-time and in vivo cellular imaging using a fiber-optic harmonograph.

The system configuration comprises an endomicroscopic probe, a confocal microscope unit, and an image signal processor. The fiber-optic harmonograph inside the endomicroscopic probe resonates a single mode fiber at ~1kHz, based on the HDHF frequency selection rule. The endomicroscopic probe is then combined with an indocyanine green (ICG) fluorescence confocal microscope unit and a phase-correctable image signal processor (ISP)