Fig. 3: Comparison of spheroid cultures on Matrigel and in microfluidic devices. | Microsystems & Nanoengineering

Fig. 3: Comparison of spheroid cultures on Matrigel and in microfluidic devices.

From: A microfluidic platform for cultivating ovarian cancer spheroids and testing their responses to chemotherapies

Fig. 3: Comparison of spheroid cultures on Matrigel and in microfluidic devices.

a Micrographs showing cells from three different PDX lines cultured on Matrigel and in microfluidic microwells. Note the difference the uniform spheroid formation in microfluidic microwells with the variable spheroid sizes on Matrigel. No spheroids could be formed for PDX line PH592 on Matrigel. Scale bar = 250 µm. b Viability for cultures from all PDX lines at day 14 comparing microfluidic (gray bar) and Matrigel (black bar) culture conditions. Microfluidic cultures showed significantly better viability (p < 0.05, n = 6) for all PDX lines except for PH704

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