Fig. 8: Assessment of chronic tissue injury.
From: A method for large-scale implantation of 3D microdevice ensembles into brain and soft tissue
Characterization of the tissue reaction to microparticles implanted for 4 weeks in the rat cortex. a Representative view of a microparticle void and the surrounding tissue with cell nuclei labeled blue (DAPI) and neurons labeled red (β3-tubulin). b Example of a tissue section with a sliced microparticle still present (arrow). c Normalized DAPI and β3-tubulin fluorescence pixel intensities plotted as a function of distance (1 µm bins) from the microparticle edge. Each trace is the average of data collected from the vicinities of n = 30 microparticles across four rats. Shaded areas represent one standard deviation. Scale bars measure 100 µm
