Fig. 4: Advanced tumor-on-a-chip models.
From: Tumor-on-a-chip: from bioinspired design to biomedical application
a Microfluidic device for drug testing and flow cytometry analysis of tumor spheroids. I Two-layered microfluidic devices with different culture chamber geometries to prepare spheroids of different sizes for drug testing. II Microscopic cross-sectional views of microfluidic devices with different culture chamber geometries. Scale bar is 500 μm. Adapted with permission178. Copyright 2016, Springer Nature. b A microfluidic platform of perfusable microvascular beds to produce vascularized three-dimensional human microtissues. Adapted with permission182. Copyright 2016, Springer Nature. c A microfluidic metastasis chip platform for microvessel formation to analyze cancer angiogenesis and intravasation. I Schematic diagram of the microfluidic metastasis chip. II Microvessel formation. III Cancer angiogenesis. IV Cancer intravasation. Adapted with permission183. Copyright 2016, Springer Nature.
