Table 1 Summary of the different types of tumor-on-a-chip
From: Tumor-on-a-chip: from bioinspired design to biomedical application
Tumor-on-a-chip models | References | Cell types | Drugs | Applications |
|---|---|---|---|---|
Lung tumor chip | Human NSCLC cell line | Tyrosine kinase inhibitors | Explain the high level of resistance to therapy in lung cancer patients and provide an experimental model to study cancer persister cells and mechanisms of tumor dormancy in vitro | |
Human alveolar epithelial cells and human pulmonary microvascular endothelial cells | Nanoparticles | Reconstitute the critical functional alveolar–capillary interface of the human lung to response to bacteria and inflammatory cytokines introduced into the alveolar space | ||
Brain tumor chip | Brain tumor stem‐like cells | Examine the function of primary patient‐derived BTSCs | ||
Glioblastoma cells (U87) | Pitavastatin Irinotecan | Develop a 3D brain cancer chip for drug screening | ||
C6 glioma cells | Colchicines | Study the cellular response to different concentrations of colchicines | ||
Liver tumor chip | HepG2/C3A MEG‐01 MES‐SA MES‐SA/DX‐5 | Doxorubicin Cyclosporine Nicardipine | Provide a combined strategy for selectively inhibiting MES‐SA/DX‐5 cell proliferation; may prove to be advantageous in vivo by specifically targeting MDR cancer with acceptable side‐effects | |
iPS C2a Functional endothelial cells Cardiomyocytes hepatocytes | Refine microtissues, establish modular multitissue platforms, and study interactive responses of cardiac, vascular and hepatic microtissues to pharmacological agents and to physiological and pathological stimuli | |||
Colorectal-tumor chip | CRC cell line HCT-116 | CMCht/PAMAM nanoparticle | Evaluate precision nanomedicine delivery | |
Breast tumor chip | MDA-MB-453, MDA-MB-231, and HCC1937 | Paclitaxel Olaparib Cisplatin | Develop a microfluidic device for a 3D breast cancer screening platform | |
Pancreatic tumor chip | MIA PaCa-2 BxPC3 HT-29 | Replicate cellular morphologies and reflect the death of endothelial cells during the metastasis process | ||
HepG2s MSCs HUVECs | Provide a suitable platform for pancreatic cancer cell growth for studying the metastasis of pancreatic cancer |
