Fig. 2: Working principle of the glucose sensor patch and characterization in a semi-infinite diffusion environment.
From: Highly integrated watch for noninvasive continual glucose monitoring
a Layer-by-layer diagram of sensor patch components. b The two-step mechanism of glucose detection: glucose oxidase (GOx)-catalyzed glucose oxidation, yielding H2O2, and Prussian blue (PB)-catalyzed H2O2 reduction. The electrocatalyst PB consumes an electron during the reaction, causing an amperometric response. c Amperometric responses of glucose sensor patches with (SP#2, 3 replicates) and without (SP#1, 3 replicates) Nafion film in the two-week test, demonstrating the long-term stability of the sensors, especially with Nafion modification. Data represent the mean ± s.d. of three replicates. d Comparison of the percentage decrease in sensor sensitivity between SP#1 and SP#2. Data represent the mean ± s.d. of three replicates. ***p < 0.001 by Student’s t-test. e Amperometric responses of SP#2 to glucose in contrast to interference components lactic acid (LA) and hyaluronic acid (HA)
