Fig. 4: Impact of nanovolcano geometry on seal resistance.
From: Impedance spectroscopy of the cell/nanovolcano interface enables optimization for electrophysiology
a Scanning electron micrograph of the different nanovolcano geometries fabricated. All scale bars correspond to 1 µm. Probe (i) and (ii) are 2.3 µm in diameter and 1.5 µm in height; however, (i) has walls with nanoscale roughness compared to (ii) smooth walls (insets). (iii) and (iv) are 1.3 µm in diameter but with decreasing wall height. (v) and (vi) are 2.3 µm in diameter with walls 50 nm high (v) or without walls (vi). For a summary of the geometrical parameters, see table in (b). where diameter and height are in units of microns. b Seal resistance of human embryonic kidney cells 24 h after plating on nanovolcanoes of different geometries. p-values correspond to a two-sided Mann‒Whitney U-test
