Fig. 2: Fluidic flow relevance in microfluidic devices.
From: Polymeric and biological membranes for organ-on-a-chip devices
a OOC developed by Delon et al. (2019) to investigate the effect of fluid shear stress on Caco-2 intestinal epithelial cells. The device is sectioned to deliver differential shear stress (top), with the highest shear stress on the left and the lowest, on the right (Image adapted from Figs. 1 and 6 from reference32). The formation of tight junctions is monitored via immunofluorescence staining (bottom) of ZO-1, a tight junction protein stained in green. b, c Hybrid insertable fluidic devices have been proposed by Shin et al. (2019) to introduce fluid flow to Transwell ® inserts (Images adapted from Figure S5 from reference34 Supplemental Information)
