Fig. 13: MPS used to investigate T-cell infiltration into solid tumor tissues.

a Physiological process of T-cell infiltration within a solid tumor recapitulated with the microfluidic platform. b Schematic structure of the multilayered blood vessel/tumor tissue chip. An endothelial cell (EC) monolayer cultured on a porous membrane and a 3D collagen gel containing tumor cells (abbreviated as TCs) are located between the top chamber and the bottom plate. c Expression levels of the adhesion molecules ICAM-1 and E-selectin on endothelial cells in the presence (Col-TC) and absence (Col) of tumor cells in a collagen gel (height = 200 μm). Adapted from Lee et al.¹²⁰