Fig. 14: Recapitulating the effects of biophysical cues on lung and breast tumor microenvironments using microfluidic devices.
From: Microphysiological systems for solid tumor immunotherapy: opportunities and challenges
Lung cancer and breast cancer cells were cultured under static and dynamic conditions. Tumor composition and architecture were evaluated by immunofluorescence techniques. Left column: pan-cytokeratin (PCK, shown in green) and vimentin (Vim, shown in red). Right column: Pan-citokeratin (PCK, green) and collagen IV (Col IV, red). Nuclei are counterstained with DAPI (blue), as shown in both columns. Adapted from Wallstabe et al.127
