Fig. 17: NK cells partially recover from MPS-induced exhaustion.
From: Microphysiological systems for solid tumor immunotherapy: opportunities and challenges
a Schematic representation of an experiment performed to measure immune cell exhaustion. b Clustergram showing changes in gene expression in the tumor-on-a-chip (ToC) compared with those in the petri dish cultures. c, d Bar graphs depicting the change in gene expression of exhaustion markers and activation/prosurvival genes in the tumor-on-a-chip device condition versus the petri dish condition. Reproduced from Ayuso et al.146
