Fig. 1: Experimental set up for cancer cell deformability measurement. | Microsystems & Nanoengineering

Fig. 1: Experimental set up for cancer cell deformability measurement.

From: Experimental measurement and numerical modeling of deformation behavior of breast cancer cells passing through constricted microfluidic channels

Fig. 1

a Experimental set up for high-speed measurements of the single breast cancer cell deformability. b Captured images from entry process of the single breast cancer cell with the diameter of 18.2 µm (passing device #1), 22.3 µm (passing device #2) and 17.9 µm (passing device #3) at five instances using the three constricted microfluidic devices (Supplementary information Video 1) Entry time starts when cell starts entering the constriction and ends when it fully enters the constriction \(({{\bf{Entry}}\; {\bf{time}}}={\boldsymbol{t}}_{{{\bf{end}}}}-{\boldsymbol{t}}_{{\bf{start}}})\). Elongation index is the ratio of the cell length after complete entry to the undeformed cell length at the start of the entry \(({{\bf{Elongation}}\; {\bf{index}}}=\frac{\boldsymbol{L}_{1}}{\boldsymbol{L}_{0}})\)

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