Fig. 4: Electrophysiology data analysis. | Microsystems & Nanoengineering

Fig. 4: Electrophysiology data analysis.

From: Fully flexible implantable neural probes for electrophysiology recording and controlled neurochemical modulation

Fig. 4: Electrophysiology data analysis.

a Representative stream trace data and sorted single unit waveforms for all three neural probes loading conditions. The grey box indicates when sinusoidal pulses were applied to trigger the drug release. The red boxes indicate time windows where the number of spikes was counted for analysis. b Summary results from all conditions. As expected, compared to baseline (blue), Glu release caused a significant increase in spike rates (green), GABA release caused a significant decrease in spike rates (grey), and non-loaded PEDOT/SNP coating showed no changes in spike rates (red). Mean ± SE, n = 36, 3 neural probes in 3 individual animals for PEDOT/SNP. n = 62, 3 neural probes in 3 individual animals for PEDOT/SNP/GABA, n = 92, 3 neural probes in 3 individual animals for PEDOT/SNP/Glu. One-way ANOVA, Dunnett’s test, **p < 0.005, ****p < 0.0001. individual animals for PEDOT/SNP/Glu. One-way ANOVA, Dunnett’s test, **p < 0.005, ****p < 0.0001

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