Table 1 List of Implantable neural probes integrated with drug delivery and electrophysiology recording capabilities
Author | Substrate | Footprint w × t (μm) | Number of Ephys recording electrodes | Impedance at 1 kHz (kΩ) | Drug delivery method | Number of chemical sites | |
|---|---|---|---|---|---|---|---|
1 | Zhanhong Jeff Du16 | Silicon | 100 × 15 4 shanks | 8 | 20 | Electrically controlled delivery (PEDOT + CNT) | 4 electrodes |
2 | Christopher M. Proctor15 | SU-8/parylene C | 80 × 54 | 2 | N/A | Electrophoretic/ microfluidic ion pump | 1 channel/5 outlets |
3 | Ximiao Wen14 | PDMS | 144 × 30 1–4 shanks | 2 on each shank | 21.4 ± 1.5 | microfluidic channel | 1 channel on each shank |
4 | Ane Altuna9 | SU-8 | 90 × 55 | 8 | >1000 | microfluidic channel | 2 channels |
5 | Hyogeun Shin66 | Silicon | 100 × 40 | 16 | 800 | microfluidic channel | 3 inlets/5 channels/1 outlet |
6 | Yousang Yoon67 | Silicon | 240 × 40 | 16 | 16 ± 2 | microfluidic channel | 1 inlet/10 channels |
7 | Pratik Rohatgi68 | Silicon probe + catheter | 165 × 165 | 16 | N/A | microfluidic channel | 1 channel |
8 | Johannes Gurke69 | Polyacrylate/parylene | 500 × 204 | 5 | 21.2 ± 6.4 | microfluidic channel | 2 channels |
9 | Anita Pongrácz70 | Silicon | 400 × 380 | 16 | >400 | microfluidic channel | 2 channels |
10 | Sven Spieth71 | Silicon | 250 × 250 2 shanks | 4 on each shank | N/A | microfluidic channel | 1 on each shank |
